Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Delayed puberty	Delayed menarche	Hypogonadism	Hypogonadotropic hypogonadism
Disease(s) Associated with PTPN11	Delayed puberty	Delayed menarche	Hypogonadism	Hypogonadotropic hypogonadism
Noonan syndrome
Noonan syndrome 1
Noonan syndrome with multiple lentigines 1

Mouse Phenotypes

abnormal lacrimal gland development

absent lacrimal glands

abnormal seminiferous tubule epithelium morphology

abnormal Sertoli cell barrier morphology

small seminiferous tubules

seminiferous tubule degeneration

increased Leydig cell number

decreased testis weight

small testis

increased lymphoblastic lymphoma incidence

hypersecretion of corticosterone

abnormal Sertoli cell barrier function

Availability

Mouse Genotype

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Camk2a-cre)2Szi/0 (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Pax6-cre,GFP)1Pgr/0 (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Inha-cre)3Zuk/0 (conditional)

Ptpn11^tm1Ckq/Ptpn11⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Ptpn11^tm1Ckq/Ptpn11⁺
Tg(Lck-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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